Formulation of tizanidine hydrochloride-loaded provesicular system for improved oral delivery and therapeutic activity employing a 2³ full factorial design.

Moreover, it can be concluded that the impact of cholesterol ratio on the size of niosomes was markedly significant, where a significant decrease ( p < 0.05) in particle size was detected when the CH ratio decreased with both types of SAA when compared at same drug amount with the exception only for F8 which acquired bigger size when the CH ratio decreased.

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