RNA degradation eliminates developmental transcripts during murine embryonic stem cell differentiation via CAPRIN1-XRN2.

Cumulative fraction analysis of our SLAM-seq data showed a highly significant increase in RNA half-life in the Caprin1 -KO cells, in both undifferentiated ESCs ( Figure 4 A) but most profoundly in RA-treated cells ( Figure 4 B) (in both cases p << 10 −50 , Kolmogorov-Smirnov test), demonstrating that RNA stability is globally elevated when CAPRIN1 is depleted and suggesting that CAPRIN1 promotes RNA degradation.

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