Ubiquitin receptors play redundant roles in the proteasomal degradation of the p53 repressor MDM2.

For S5A , the Pearson's correlation coefficient ( r ) indicated, at best, a weak association between a smaller negative gene effect score and p53 mutation, which just failed to reach significance ( r = 0.10, P = 0.07; Fig. 7A,B ).

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There was a tendency for the depletion of RAD23B in combination with S5A to increase p53 stability further, but this failed to reach significance (Fig. 3E , upper left panel).

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