Applying multi-omics techniques to the discovery of biomarkers for acute aortic dissection.

Sequencing technology and genealogical co-isolation analysis identified 257 pathogenic or potentially pathogenic genes, accounting for 88.89% (64/72) of all genes encoding the collagen and matrix metalloproteinase systems, indicating that collagen loss and destruction as well as disruption of the matrix metalloproteinase system may be significant in the pathogenesis of AAD ( 90 ).

also in 13,097 other papers