of borderline significancep = 0.07
However, the drop of 20 u/L in ALT was of borderline significance (p = 0.07) and in one subject with fatty liver, there was normalization of transaminases.
However, the drop of 20 u/L in ALT was of borderline significance (p = 0.07) and in one subject with fatty liver, there was normalization of transaminases.
There was a significant decrease in total cholesterol (0.72 mmol/L; p < 0.05), triglycerides (0.53 mmol/L; p < 0.01) and borderline significant decreases in HbA1c (0.27%; p = 0.07) and LDL (0.68 mmol/L; p = 0.07) with a significant increase in HDL (0.10 mmol/L; p = 0.01).
In this context, the magnitude of weight loss in the BROAD study is highly significant as it may be associated with resolution of NASH and fibrosis regression in 80-90% of subjects [ 7 - 9 ] as well as improvement in steatosis and a reduction in hepatocellular lipid levels [ 10 ].