Progranulin from different gliocytes in the nucleus accumbens exerts distinct roles in FTD- and neuroinflammation-induced depression-like behaviors.

In one clinical connectivity analysis, individuals who experienced the greatest deterioration in total mood after peripheral inflammation showed a highly significant reduction in the functional relationship between the subgenual anterior cingulate cortex and activity within the NAc, and this finding supports that of an animal study showing that immune stimulation-induced depression behavior in mice was accompanied by reduced neural activity in the NAc [ 12 ].

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