Normal Ranges of Thiopurine Methyltransferase Activity Do Not Affect Thioguanine Nucleotide Concentrations With Azathioprine Therapy in Inflammatory Bowel Disease.

Crohns Colitis 360 · 2020 · PMC9802184 · PMID 36776499

Europe PMC DOI

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closest p · 1.2× alpha

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boldest claim

The sentences

of borderline significanceP = 0.06so close (0.05 < p ≤ 0.1)

Exploratory multivariate regression to identify predictors of clinical remission identified a TPMT of <1.4 times LLN to be of borderline significance (odds ratio [OR] = 3.3, 95% confidence interval: 0.96, 12.6, P = 0.06), whereas a 6-TGN > 230 pmol/8 × 10 8 RBCs was a significant predictor (OR = 3.6, 95% confidence interval: 1.1, 12.2, P = 0.04), when controlling for sex, age, IBD type, and smoking status.

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