Adaptation to HLA-associated immune pressure over the course of HIV infection and in circulating HIV-1 strains.

PLoS Pathog · 2022 · PMC9803285 · PMID 36525463

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likely to be significantno p-value reported

Notably, in individuals diagnosed earlier in the epidemic and withheld ART for some time or individuals with poor ART adherence, we predict that the level of adaptation is likely to be significant, particularly in the proteins Gag and Nef [ 30 ].

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