Glycemic Variability in Early Pregnancy May Predict a Subsequent Diagnosis of Gestational Diabetes.

In the other studies that had null findings, one examined SD in all three trimesters, with the outcome of GDM showing only a borderline significant association when compared to those who did not develop GDM in a small sample of 30 participants. 19 One other study had inconsistent associations when examining SD in the second and third trimesters, and reported nonsignificantly higher SD only in the third trimester, but lower SD in the second tri

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Overall, the participants who were diagnosed with GDM at 24–31 weeks showed an overall trend of higher SD and MAGE that was already evident in first trimester, with values increasing by the second trimester and sustained through to the third trimester compared to those who were not diagnosed with GDM ( Supplementary Figure S2 ).

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