The meningeal transcriptional response to traumatic brain injury and aging.

Other highly significant subcluster-defining genes in the ‘Anti-Inflammatory’ macrophage population included Stab1, Nrros , and Dab2 , which are known to be expressed on healing macrophages, and are important for repressing reactive oxygen species and limiting type I IFN responses ( Park et al., 2009 ; Noubade et al., 2014 ; Hung et al., 2016 ; Figure 2—figure supplement 1a ). ‘Resolution Phase’ macrophages do not fall into either the M1 classically activated or M2 alternatively activated macrophage categories and are believed to play a regulatory role following an inflammatory event ( Stables et al., 2011 ).

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