marginal significancep = 0.05
Cervical Pessary + Vaginal Progesterone vs Vaginal Progesterone: RCT and Non-RCTs Meta-analysis of total RCTs and non-RCTs indicated a marginal significance was achieved in reducing the risk of PTB < 34 weeks of gestation (RR = 0.63, 95% CI: 0.39–1.01, p = 0.05) by cervical pessary + vaginal progesterone combined treatment when comparing with vaginal progesterone alone (Fig. 2C ).