highly significantP <0.05
In the present study, we observed that (i) the frequency of the heterozygote CT genotype at position +3422 (rs17875408) was significantly higher in cervical cancer patients than in healthy women ( P <0.05), suggesting that the +3422 C/T genotype may be a highly significant risk factor for cervical cancer; (ii) the frequency of the UTR-1/UTR-3 diplotype in patients was significantly higher than that in healthy women ( P <0.05), which may play a key role in cervical carcinogenesis; (iii) HLA-G 3’UTR polymorphic sites may influence the sHLA-G plasma level in patients’ peripheral blood, especially 14 bp Ins/Del (rs371194629) and + 3142 C/G (rs1063320); and (iii) the sHLA-G level had good diagnostic performance in differentiating patients with cervical cancer from healthy women, suggesting that sHLA-G can be a supplementary biomarker of cervical cancer.