Allosteric regulation in STAT3 interdomains is mediated by a rigid core: SH2 domain regulation by CCD in D170A variant.

2.03E-306, between M2 and M3), how many freedom degrees have been considered? By the way, but this is a minor point, I definitively prefer to distinguish between p < 0.05 for statistically significant correlations and < 0.001 for highly significant ones, (What is the real difference between 2.03E-306 for M2/M3 and 0 for M1/M2?).

also in 132,142 other papers

Additionally, we have observed that even fairly significant alterations of the CCD structure, such as the kinked conformation of α 1 explored by the D170A variant, do not correlate with changes to SH2 structure except via the rigid core.

also in 581 other papers