Individual radiosensitivity reflected by γ-H2AX and 53BP1 foci predicts outcome in PSMA-targeted radioligand therapy.

Eur J Nucl Med Mol Imaging · 2023 · PMC9816192 · PMID 36136101

Europe PMC DOI

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closest p · 1.0× alpha

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boldest claim

The sentences

borderline significanceP = 0.05actually significant

Consistently, in univariate Cox-regression analysis, baseline 53BP1 foci demonstrated borderline significance for predicting PSA-PFS under [ 177 Lu]Lu-PSMA RLT ( P = 0.05).

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failed to reach significanceno p-value reported

First, although we were able to demonstrate consistent and robust results, the baseline DDR-marker closely failed to reach significance in predicting early PSA-PD and PSA-PFS due to the small number of enrolled patients in this prospective study.

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borderline significantno p-value reported

In addition, baseline γ-H2AX foci per cell ( P = 0.1) and SUV max ( P = 0.06) showed borderline significant associations.

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