Paternal dietary ratio of n-6: n-3 polyunsaturated fatty acids programs offspring leptin expression and gene imprinting in mice.

3.4 Correlation between leptin and imprinted genes in the adipose tissue Linear correlation analysis indicated that adipose leptin expression was positively correlated with the expression of H19 , Igf2r , Plagl1 , and Kcnq1ot1 in juvenile F1 males and females; negatively correlated with the expression of Kcnq1ot1 in adult F1 males, with a negative trend toward significance for the Cdkn1c expression; and positively correlated with the expression of Plagl1 in adult F2 females, with a positive trend toward significance for the Kcnq1ot1 expression ( Figure 5 ).

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