A Single Episode of Cortical Spreading Depolarization Increases mRNA Levels of Proinflammatory Cytokines, Calcitonin Gene-Related Peptide and Pannexin-1 Channels in the Cerebral Cortex.

Int J Mol Sci · 2022 · PMC9820231 · PMID 36613527

Europe PMC DOI

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0.0007

closest p · 0.0× alpha

0.0007

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The sentences

highly significantp = 0.0007actually significant

Friedman ANOVA showed highly significant changes in cortical mRNA expression of all targeted genes—Il1b ( p = 0.0007), TNF ( p = 0.00002), Il6 ( p = 0.0015), TGFb ( p = 0.0098), Panx1 ( p = 0.0001), and CGRP ( p = 0.0039)—at three hours after the injury.

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