Role Played by Paraoxonase-2 Enzyme in Cell Viability, Proliferation and Sensitivity to Chemotherapy of Oral Squamous Cell Carcinoma Cell Lines.

Concerning HOC621 cell line ( Figure 6 B), the following considerations can be reported: (i) by considering the ratio A 3010 /A 2960 , an higher value was found in PON2-silenced cells (pLKO.1-647) compared with controls (pLKO.1-puro) at 72 h, even if both cell groups showed an increasing trend from 24 h to 48 h; (ii) as regards the band area ratios A 2925 /A 2960 and A 1740 /A 1655 , they showed an increasing time-dependent trend, with higher values in pLKO.1-647 with respect to pLKO.1-puro, at all time points; (iii) concerning the ratio A 1170 /A 1655 , both cell groups showed similar values at 24 and 72 h, while a significant difference was observed at 48 h, with cells downregulating PON2 (pLKO.1-647) displaying a higher value compared with reference specimen (pLKO.1-puro). 2.5.

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