Imbalance in Bone Morphogenic Proteins 2 and 7 Is Associated with Renal and Cardiovascular Damage in Chronic Kidney Disease.

Int J Mol Sci · 2022 · PMC9820638 · PMID 36613483

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Moreover, a highly significant increase of BMP-2 was observed in a small subgroup of CKD patients with atrial fibrillation and 25-OH-cholecalciferol deficiency. 25-OH-cholecalciferol stimulates sclerostin and inhibits BMP2 production, thus mitigating osteoblastic transdifferentiation and calcification of soft tissues in a murine CKD model [ 40 ].

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