Even though statistical significance was not achieved, an evident trend is visible, suggesting that RG108 is an inhibitor of DNA methylation and increases the expression of many genes, including genes from the S100 family. 2.4.
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S100A8 and S100A12 Proteins as Biomarkers of High Disease Activity in Patients with Rheumatoid Arthritis That Can Be Regulated by Epigenetic Drugs.
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Interestingly, this concentration was statistically significant in the eRA group (disease duration of less than a year), which was probably due to the intensive and prolonged immunosuppressive treatment of patients with aRA where there is only an elevated trend.