Effects of Histamine and the α-Tocopherol Metabolite α-13'-COOH in an Atopic Dermatitis Full-Thickness Skin Model.

Molecules · 2023 · PMC9824170 · PMID 36615633

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markedly significantp < 0.01actually significant

Moreover, a markedly significant increase in the inflammatory marker of atopic dermatitis severity, namely IL-8, was found after 1 h (7.7 ± 2.6-fold, p < 0.01; Figure 2 c) 24 h (13.1 ± 2.3-fold, p < 0.001; Figure 2 c) and 48 h (5.2 ± 0.3-fold, p < 0.001; Figure 2 c) of incubation with the combination of T H 2 cytokines and histamine.

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