Vitamin D, Folic Acid and Vitamin B₁₂ Can Reverse Vitamin D Deficiency-Induced Learning and Memory Impairment by Altering 27-Hydroxycholesterol and S-Adenosylmethionine.

The mRNA expression of CYP27A1 and CYP27B1 were upregulated in the VDD group ( p < 0.001), VDR had a decreasing trend compared with the CON group in the brain; while the mRNA expression of CYP27A1 ( p = 0.002, p < 0.001) and CYP27B1 ( p = 0.008, p < 0.001) were downregulated, VDR ( p = 0.044, p = 0.010) was upregulated in the VDD + VD group and VDD + VD-FA/VB 12 group compared with the VDD group in the brain.

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