Age-associated epigenetic changes in mammalian sperm: implications for offspring health and development.

Hum Reprod Update · 2023 · PMC9825272 · PMID 36066418

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highly significantno p-value reported

Although these age-associated changes in sperm methylation are highly significant and consistent in their location, more direct evidence of their biological implications is needed.

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a weak trendno p-value reported

Only a weak trend for the subjects of the older grandfather group to display reduced methylation at the 140 aDMRs known to undergo hypomethylation with age was found.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.