Pharmacological evidence for the possible involvement of the NMDA receptor pathway in the anticonvulsant effect of tramadol in mice.

AIMS Neurosci · 2022 · PMC9826747 · PMID 36660072

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extremely significantP < 0.0001actually significant

Interestingly, our two-way ANOVA revealed that this increment is only owing to the extremely significant effect of tramadol treatment ( F [1, 30] = 21.34, P < 0.0001), since no statistically significant effect was seen for the time of tramadol administration ( F [2, 30] = 1.926, P=0.1633) or for the time-treatment interaction ( F [2, 30] = 1.557, P = 0.2274).

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