Adverse karyotype subcategories in acute myeloid leukemia display significant differences in mutation composition and transplant-augmented survival.

Haematologica · 2023 · PMC9827171 · PMID 36073516

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borderline significanceP =0.06so close (0.05 < p ≤ 0.1)

In age-adjusted multivariable analysis, using NK-AML as a reference, survival was adversely affected by MK (hazard ratio n [HR] 3.8, 95% confidence interval [CI]: 2.9-4.8; P <0.001), CK (HR 3.1, 95% CI: 2.1-4.4; P <0.001), and RAV (HR 5.6, 95% CI: 2.3-13.7; P <0.001); in addition, borderline significance for adverse outcome was also noted for monosomy 7 ( P =0.06) and -5/5q- ( P =0.09).

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