Molecular Docking Studies, Synthesis and Biological Evaluation of Substituted Pyrimidine-2,4-diamines as Inhibitors of Plasmodium falciparum Dihydrofolate Reductase.

For the R substituents there was less of an obvious trend, however on average compounds bearing a cyclopropyl group in the 6‐position gave the best IFD docking scores, followed by phenyl and cyclohexyl substituents.

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