The RNA export and RNA decay complexes THO and TRAMP prevent transcription-replication conflicts, DNA breaks, and CAG repeat contractions.

Quantification of the number of foci in each strain showed a highly significant increase between wild type and each indicated mutant, with the effect being smallest for the rnh1Δrnh201Δ strain (1.3-fold increase, p < 0.001), followed by a further significant 1.6-fold increase in the thp2Δ nuclei, and an even more striking 2.2-fold increase in trf4Δ nuclei ( p < 0.0001 for both) ( Fig 4B ; Table L in S1 Tables ).

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