Bioinformatics analysis on the expression of GPX family in gastric cancer and its correlation with the prognosis of gastric cancer.

3.1.4 Analysis of GPX4 expression results According to the Kaplan-Meier Plotter database, increased expression of GPX4 mRNA was not significantly correlated with OS in GC patients ( Figure 4 A) ( P > 0.05), and the Lauren classification results showed that the increase of GPX4 mRNA expression was not correlated with the OS in gastrointestinal cancer ( Figure 4 B) and mixed GC ( Figure 4 D) patients ( P > 0.05), while OS showed a favorable trend with the increase of GPX4 mRNA low expression, which was statistically significant in diffuse GC patients ( Figure 4 C) ( P < 0.05). 3.1.5 Analysis of GPX5 expression results The Kaplan-Meier Plotter database results revealed that an increase in GPX5 mRNA expression in GC patients was significantly correlated with OS ( Figure 5 A) (P0.05), and Lauren classification results showed that an increase in GPX5 mRNA low expression in GC patients showed a favorable prognostic trend in OS.

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