ATR inhibition overcomes platinum tolerance associated with ERCC1- and p53-deficiency by inducing replication catastrophe.

T / C < 42% is considered significant activity by the Drug Evaluation Branch of NCI; T / C < 10% is highly significant activity; (iv) activity rating, to facilitate direct comparisons of activity with standard agents or between tumor models, as reflected in relative log 10 kill values (by this criterion, a gross log 10 tumor cell line > 2.8 is considered highly active (++++); 2.0–2.8 (+++ activity); 1.3–1.9 (++ activity); 0.7–1.2 (+ activity) and a value <0.7 is considered inactive) ( 18–21 ).

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