Eleven-Year Trend of Drug and Chemical Substance Overdose at a Local Emergency Hospital in Japan.

Cureus · 2022 · PMC9835393 · PMID 36644086

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an overall trendno p-value reported

Conclusions As an overall trend, there was a decrease in overdoses, possibly due to Japan's overdose countermeasures since 2010.

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a decreasing trendno p-value reported

Conclusion: There was a decreasing trend in overdose, and OTC medicines, sedatives, and anxiolytics were the primary medications causing overdose.

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an increasing trendno p-value reported

OTC antipyretic analgesics and cold medicines were the most common suspected overdose drugs, with an increasing trend in the later years.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.