Large-scale genomic analysis of Mycobacterium tuberculosis reveals extent of target and compensatory mutations linked to multi-drug resistant tuberculosis.

Of the 171 isolates with a putative resistance mutation (Figure S1), 107 (62.6%) had an available DST result for INH, with 99 reporting a resistant phenotype leading to a highly significant association between the putative drug resistance mutations and DST phenotype (Chi-squared P < 1.4 × 10 –18 ).

also in 132,142 other papers