Differential analysis of the genomic windows of the OC and HC groups revealed a total of 66 windows exhibiting extremely significant proportional differences in short-long fragments, highlighting position-dependent alterations of cfDNA fragments, and the features of these 66 windows can be used to distinguish OC patients from healthy populations. 5’-end motifs DNA fragments are nonrandomly cut into cfDNA by the nuclease, and each endonuclease has a preferred base type [ 10 , 11 ].
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Can circulating cell free DNA be a promising marker in ovarian cancer? - a genome-scale profiling study in a single institution.
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