A numerical trend of lower rates of serious infections among higher quartiles of baseline IgG level was observed (by baseline IgG quartile, serious infections rates per 100 participant-years [95% CI] were as follows: Q1, 1.63 [0.95–2.61]; Q2, 1.55 [0.90–2.48]; Q3, 1.51 [0.86–2.45]; and Q4, 1.11 [0.57–1.94]) [ 37 ].
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Systematic literature review of immunoglobulin trends for anti-CD20 monoclonal antibodies in multiple sclerosis.
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