highly significantp < 0.001
In the K.M study of mRCC, the difference in OS between the variables of the lung metastasis and liver metastasis were noted among most of the variables, with survival benefits restricted to patients in lung metastasis in the ICI era, such as younger age (≤64), clear cell carcinoma, papillary cell carcinoma, radiotherapy status, chemotherapy, and surgery showed a highly significant difference in OS median (9 months vs. 4 months, 7 months vs. 3 months, 6 months vs. 4 months, 11 months vs. 6 months, and 21 months vs. 8 months; p < 0.001) respectively Figure 5 Table 2 .