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Osteopontin contributes to virus resistance associated with type I IFN expression, activation of downstream ifn-inducible effector genes, and CCR2<sup>+</sup>CD115<sup>+</sup>CD206<sup>+</sup> macrophage infiltration following ocular HSV-1 infection of mice.

Front Immunol · 2022 · PMC9846535 · PMID 36685562

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Conversely, OAS3a was elevated in the cornea of WT mice in comparison to OPN KO animals although it did not quite reach significance ( Figure 2F ).

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