Comprehensive expression analysis with cell-type-specific transcriptome in ALS-linked mutant SOD1 mice: Revisiting the active role of glial cells in disease.

We found a significant decrease or a decreasing trend in the motor neuronal marker Mnx1 (motor neuron and pancreas homeobox 1) depending on each mutant SOD1 mouse, indicating a loss of motor neurons, and significant upregulation or upregulation trend of Gfap and Itgam , indicating activation or proliferation of astrocytes and microglia ( Figure 1B and Supplementary Figure 1 ).

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