The PSEN1 E280G mutation leads to increased amyloid-β43 production in induced pluripotent stem cell neurons and deposition in brain tissue.

Brain Commun · 2023 · PMC9847549 · PMID 36687397

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a notable trendno p-value reported

Full-length PSEN1 levels statistically differed across lines ( P = 0.04), with significantly increased levels in the R278I line compared with the control group ( P = 0.03), with a notable trend for increased levels in the E280G lines, see Fig. 4B .

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