Time-Resolved Imaging of High Mass Proteins and Metastable Fragments Using Matrix-Assisted Laser Desorption/Ionization, Axial Time-of-Flight Mass Spectrometry, and TPX3CAM.

In both cases 1 and 2, the TPX3 data registers more events than the simulated TPX data due to its multihit capabilities. The green trace in Figure 4 a,c shows the ratio of signal intensities in simulated TPX and TPX3 modes and shows a decreasing trend with an increase in m / z and thus demonstrates that utilizing TPX3 over TPX improves detection efficiency for higher m / z species when detected in the presence of ions with lower m / z .

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