The age-adjusted incidence is reported to be 20/100,000 population.[ 2 ] Tobacco and alcohol act synergistically and are the two most important etiological factors responsible for about 75% of SCC.[ 3 ] Studies have reported changing trends in the incidence of SCC showing an increasing trend, particularly in younger age group, especially in the absence of the above risk factors.
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Association of human papillomavirus and Epstein-Barr virus with squamous cell carcinoma of upper aerodigestive tract.
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This finding was also highly significant with a P value of 0.000.