Inflammatory Bowel Diseases Before and After 1990.

Gastro Hep Adv · 2023 · PMC9851382 · PMID 36686985

Europe PMC DOI

hedged sentences

0.0580

closest p · 1.2× alpha

0.0580

boldest claim

The sentences

borderline significantP = .058so close (0.05 < p ≤ 0.1)

CD-GRS showed a borderline significant decrease ( P = .058) in multivariate analysis post 1990 but only when excluding surgery in the model; surgery significantly decreased post 1990 in both CD and UC.

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a trend toward significanceP = .058so close (0.05 < p ≤ 0.1)

However, when we excluded surgery from multivariate analysis, the beta-coefficient decreased from −0.097 to −0.412 (95% CI −0.838 to 0.0137) with a trend toward significance ( P = .058) suggesting that a lower genetic risk threshold may be permissible for disease to develop in more recent decades.

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