The Triterpenoid CDDO-Methyl Ester Redirects Macrophage Polarization and Reduces Lung Tumor Burden in a Nrf2-Dependent Manner.

However, male Nrf2 KO mice had a 2-fold increase ( p < 0.05) in average tumor burden (4.05 ± 0.6 mm 3 in males compared to 1.9 ± 0.3 mm 3 in females) and an overall trend toward increased severity in tumor histopathology compared to female Nrf2 KO mice ( Table S3 ).

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