Meta-analysis of anxiety, mostly based on scales or questionnaires, showed marginally significant association with 45% increase in the Alzheimer disease risk. 28 The median follow-up time being 9 years, reverse-causation may have led to higher Alzheimer disease risk as compared with our results on nervousness and stress ( Table 3 ), which were not significant after excluding individuals with follow-up time less than 10 years.
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Association Between Psychological Distress and Incident Dementia in a Population-Based Cohort in Finland.
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