Effects of Mavacamten on Measures of Cardiopulmonary Exercise Testing Beyond Peak Oxygen Consumption: A Secondary Analysis of the EXPLORER-HCM Randomized Trial.

However, although there was no significant difference in VO 2 at the ventilatory threshold (LS mean difference, 0.6 mL/kg/min; 95% CI, −0.03 to 1.17 mL/kg/min; P = .06) between mavacamten and placebo in exploratory analyses that were not adjusted for multiplicity, a numerical trend toward improvement was observed ( Figure 3 ; Table 2 ).

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