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Multizonal observational study conducted by clinical practitioners on evolocumab use in subjects with hyperlipidemia in Saudi Arabia and Kuwait: Results from the ZERBINI study.

PLoS One · 2023 · PMC9858091 · PMID 36662739

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a decreasing trendno p-value reported
Other studies also report few adverse events related to evolocumab, and a decreasing trend in injection-site reactions with longer duration of evolocumab use [ 20 , 22 , 25 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.