highly significantp ≤ 0.01
Statistical analysis was conducted by ANOVA two-tailed test for multiple comparisons using Tukey–Kramer’s or Dunnett’s approach, as indicated: *** p ≤ 0.001 highly significant; ** p ≤ 0.01 very significant; * p ≤ 0.05 significant; not significant (n.s.) p > 0.05.