marginally significantp = 0.059
Cdkn2a , which is located on chromosome 4, was affected by interstitial deletions in 15% and 24% and by copy-neutral LOHs in 19% and 0% of TLs in the 95 and 65 kcal groups, respectively; no terminal deletions were detected, and the total LOH frequency was 33% and 24%, respectively ( Table 1 ), indicating a marginally significant CR-related decrease in the frequency of copy-neutral LOHs ( p = 0.059).