Regulation Effectiveness and Mechanism of Biotransformation Pathway on the Toxicity of Microcystin-LR Target to Protein Phosphatase 2A.

Int J Environ Res Public Health · 2023 · PMC9859369 · PMID 36673721

Europe PMC DOI

hedged sentences

0.0100

closest p · 0.2× alpha

0.0100

boldest claim

The sentences

extremely significantp < 0.01actually significant

Significance levels were classified as extremely significant ( p < 0.01), significant ( p < 0.05), or not significant ( p > 0.05).

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highly significantno p-value reported

At the level of p < 0.01, the combination areas for Ala 1 →PP2A, Adda 5 →PP2A and “Mdha 7 ”→PP2A, the positive accessible surface area for Glu 6 →PP2A, the polar surface area for “Mdha 7 ”→PP2A, the hydrogen bonds for Ala 1 ←Arg 268 , Adda 5 ←His 118 , and the amino acid associated with the binding of the phosphate group for Arg 214 had a highly significant correlation with the toxin toxicity at the three tested concentrations.

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