Comparative Genetic Association Analysis of Human Genetic Susceptibility to Pulmonary and Lymph Node Tuberculosis.

Interestingly, out of the 7 SNPs from the discovery panel which was significantly associated in ( Table 1 and Table 2 ), only rs3024498 of IL10 gene achieved a borderline significance ( p = 0.07) ( Table S4a ) and the rest was not replicated in the validation cohort for LNTB.

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Interestingly, all the interactions of IL4, an anti-inflammatory cytokine with other proinflammatory cytokines such as IL12 and TNFB showed a very high risk (18-fold risk) with very highly significant p -values.

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The significant and borderline significant associations are enlisted in Table 1 .

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