an increasing trendp = 0.15
Laboratory Parameters Values of serum urea showed an increasing trend in the EX group from baseline to the 5-year follow-up (88 ± 34 to 106 ± 40 mg/dL; t = 0.81; p = 0.15), whereas a significant increasing trend was noted in the CO group from baseline to the 5-year follow-up (86 ± 38 to 136 ± 71 mg/dL; t = 2.89; p = 0.001), with a significant between-group difference ( p = 0.039).