Barely Significant
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Effects of switching from sacubitril/valsartan to valsartan alone on plasma levels of natriuretic peptides and myocardial remodeling in heart failure with reduced ejection fraction.

BMC Cardiovasc Disord · 2023 · PMC9862569 · PMID 36681789

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highly significantno p-value reported
However, the changes in plasma natriuretic peptides levels, especially ANP levels were robust and highly significant.

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