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A Simple Epidemiologic Model for Predicting Impaired Neutralization of New SARS-CoV-2 Variants.

Vaccines (Basel) · 2023 · PMC9863154 · PMID 36679973

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an increasing trendno p-value reported
The number of mutations within the spike protein of each SARS-CoV-2 Omicron sublineage, along with the cumulative number of COVID-19 cases and COVID-19 vaccine doses administered worldwide displayed an increasing trend over time, whilst the value of FFRNT 50 exhibited a progressive decline from the BA.4/5 sublineages that first appeared in January 2022, to the last XBB.1 strain that was first described in August 2022.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.